Men suffering from potency issues are not generally ready to share their troubles with specialists, but prefer to purchase different pills or biologically active promising enhancement of male strength substances at drug stores. But not all of them bring expectation effect. Research studies and patients’ feedback confirm that tadalafil-based pills are quite effective for sexual issues. Therefore, they are very popular with men.
Tadalafil is an international name of synthetic drug that was first developed by American scientists in 2003. They patented their invention under the name, Cialis. It became the first remedy containing tadalafil as active substance. Later on, there appeared a wide range of medicinal products based on tadalafil.
Tadalafil takes impact on reactions occurring during the process of sexual excitement in penile cavernous bodies. Sexual desire causes vasodilation of penile vessels resulting in enhanced blood supply to penis and erection. Potency issues connected with different diseases is affected by impaired blood filling of penis and incapacity to have a fully-realized sexual intercourse.
Tadalafil intake should be started with minimal dosage in order to avoid negative consequences of side-effects. Vasodilation of vessels is generally affected by special substance, cyclic guanosine monophosphate, which is contained in smooth muscle cells. But cyclic guanosine monophosphate gets quickly destroyed under the impact of PDE5, enzyme that is located in penile vessels. Tadalafil is a selective PDE5 inhibitor. All tadalafil-based remedies block the destruction of cyclic guanosine monophosphate causing long-term relaxation of the vessels of penile cavernous bodies, their good blood filling and fully-realized and long-standing erection. Therefore, tadalafil is indicative to therapy of erectile dysfunction. In case sexual arousal and stimulation are absent, tadalafil doesn’t take its action.
The original medication, Cialis, which appeared at drug stores several years after Viagra (sildenafil) became the second medicine of synthetic origin for male potency boost. Sildenafil and tadalafil inhibit PDE5, but sildenafil has much more side-effects and contraindications while application and shorter time of action.
The remedy may be applied long before planned coitus, and side-effects are less pronounced than with Viagra.
Nevertheless, the following adverse effects may take place:
- Headaches and vertigo;
- Allergic reactions;
- Digestion issues;
- Enhanced weariness;
- Pain in muscles and back.
Tadalafil has a number of contraindication non-observance of which will lead to negative consequences for organism. This remedy is not to be taken by persons under 18 years of age. Co-administration with nitrates and alpha adrenoceptor antagonists is strictly prohibited.
Physicians do not allow taking tadalafil in the following cases:
- Hypertension and uncontrolled blood pressure drops;
- Hepatic impairment;
- Unstable angina;
- Degenerative changes of eye retina;
- Apoplectic attack or operations on heart undergone less than half a year ago.
A patient must study the description and instruction to tadalafil before usage. The pills are taken perorally not less than 15-20 minutes prior to sexual intercourse regardless of food intake. Tadalafil is not compatible with alcoholic beverages. Its action lasts within thirty-six hours. Doctors recommend initial administration of the drug from 5 mg. In case side-effects are not observed or not pronounced, next time it is advised to administer tadalafil in the dose of 20mg. In case sexual activity is not regular, tadalafil may be applied 1 pill per 2-3 times a week. Such method of administration will ensure a stable erection for a man. In case of rare sexual relations, tadalafil is recommended right before coitus. Decrease or increase of daily dosage is agreed with a doctor.