Besides mirtazapine (the active ingredient of the drug), it contains lactose, silicon dioxide colloidal anhydrous, corn starch, hydroxypropyl cellulose, magnesium stearate, titanium dioxide, polyethylene glycol and some others.
Antidepressant Mirtazapine (Remeron) is available in a form of pills with 15 mg, 30 mg and 45 mg dosage. Mirtazapine dose for sleep is usually 15 mg, in some cases the healthcare provider can prescribe 30 mg depending on many factors.
The main component of the drug is an active central presynaptic antagonist of α2 receptors, capable of increasing noradrenergic and serotonergic transmission of the nervous system. Serotonergic transmission is enhanced through 5-HT1 receptors, since mirtazapine can block 5-HT2 and 5-HT3 receptors. Also, the drug blocks H1-receptors, which determines its sedative effect and that is the reason why mirtazapine for sleep is so effective. For therapeutic doses of Mirtazapine, the anticholinergic activity or a negative effect on the cardiovascular system are not likely.
After ingestion, the drug is quickly and fully absorbed and has 50% bioavailability. This fact helps to prescribe the right mirtazapine dosage for sleep (15 mg). The maximum concentration in the blood plasma is reached within 2 hours. About 85% of mirtazapine comes into contact with plasma proteins. Achievement of stable concentration is observed in 3-4 days, then the accumulation decreases. Pharmacokinetic parameters of the drug have a linear dependence on the dose. Food intake does not affect the pharmacokinetics of the active substance.
Mirtazapine is characterized by active metabolism with the formation of several metabolites. Removal of the drug from the body occurs with urine and feces.
Mirtazapine (Remeron) – indications and contraindications for use
The main indications for the administration of Mirtazapine are various forms of depressive conditions. In some cases, mirtazapine can be prescribed to treat poor sleep, as scientific data say about its major effect on sleep continuity and sleep architecture in depressed patients.
Contraindications for use are the same as for other antidepressants: high sensitivity to the active ingredient and other components of the drug and simultaneous administration of MAO inhibitors.
Mirtazapine sleep side effects
Antidepressant mirtazapine side effects are usually difficult to observe, as depression often includes symptoms that may be side effects of Mirtazapine. Therefore, it is difficult to determine their relationship during the treatment course.
Particularly often there are side effects in the form of: drowsiness, sedation, dry mouth, increased body weight, increased appetite, increased fatigue and dizziness.
Also, some abnormalities related to blood, lymphatic, cardiovascular, digestive, endocrine, or nervous system, metabolism, and so on can be side effects of Remeron (Mirtazapine)
Side effects may include the development of mental disorders: troubles with sleep, confusion, anxiety, nightmares, mania, hallucinations and other and common disorders (peripheral edema and increased fatigue).